The following are representative publications focusing on Resonant Molecular Signaling formulations in our pipeline.


Viral infections


Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial Results and Improved Outcome After Post-hoc Analysis. Mamber SW, Hatch T, Miller CS, et al. Journal of Evidence-based Integrative Medicine. 2022 Jan-Dec;27:2515690X221078004. DOI: 10.1177/2515690×221078004. PMID: 35142535; PMCID: PMC8841908.


Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity ? Stephen W Mamber, Steven Krakowka, Jeffrey Osborn, Lloyd Saberski, Ryan G Rhodes, Albert E Dahlberg, Sunthorn Pond-Tor, Kara Fitzgerald, Neal Wright, Sarah Beseme, John McMichael. Sphere. 2020 May 13;5(3):e00288-20. doi: 10.1128/mSphere.00288-2


Muscular dystrophy


Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmdmdx Mice. Volkan Gurel, Jeremy Lins, Kristyn Lambert, Joan Lazauski, James Spaulding, John McMichael. Dose Response. 2015 ;13(4):1559325815616351. doi: 10.1177/1559325815616351


Other Relevant Publications:



Allergy and Cross-Reactivity. Sue C. Killian, MS, with John McMichael, PhD. Indianapolis: Xlibris, 2017 (book).

Allergy Induced Back Pain: A Report of Two Cases. Sue Killian and John McMichael. Journal of Allergy Disorders and Therapy, Vol. 2, Issue 1, 1-4, 2015.


Inflammation / Wound Healing


Streptolysin-O/Antibiotics Adjunct Therapy Modulates Site-specific Expression of Extracellular Matrix and Inflammatory Genes in Lungs of Rhodococcus equi Infected Foals. Volkan Gurel, Kristyn Lambert, Allen E. Page, Alan T. Loynachan, Katherine Huges, John F. Timoney, Michael Fettinger, David W. Horohov, John McMichael. Vet Res Commun. 2013;37(2):145-54. doi: 10.1007/s11259-013-9557-y


The use of streptolysin O (SLO) as an adjunct therapy for Rhodococcus equi pneumonia in foals. David W. Horohov, Alan T. Loynachan, Allen E. Page, Katherine Hughes, John F. Timoney, Michael Fettinger, Thomas Hatch, James G. Spaulding, John McMichael. Vet Microbiol. 2011;154(1-2):156-62. doi: 10.1016/j.vetmic.2011.06.037.


Effects of Streptolysin O on Extracellular Matrix Gene Expression in Normal Human Epidermal Keratinocytes. Stephen W. Mamber, Volkan Gurel, Ryan G. Rhodes, John McMichael. Dose-Response 2011;9(4):554-78. doi: 10.2203/dose-response.10-050.Mamber.


Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1. Emily H. Hall, Volkan Gurel, Albert E. Dahlberg, John McMichael, David L. Brautigan. Cell Signal. 2011 Dec;23(12):1972-7. doi: 10.1016/j.cellsig.2011.07.007. Epub 2011 Jul 20.


Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro. Tomic-Canic, M, Mamber SW, Stojadinovic O, Lee B, Radoja N, McMichael. Wound Repair Regen. Jan-Feb 2007;15(1):71-9. doi: 10.1111/j.1524-475X.2006.00187.x


Respiratory Disease


Microdose DNA for the Treatment of Acute and Chronic Respiratory Diseases and Otitis Media. Stephen Mamber and John The Journal of the American Nutraceutical Association, Vol. 9, No. 1, 13-22, 2006.




Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. John E. McGeary, Volkan Gurel, Valerie S. Knopik, James Spaulding, John McMichael. Neuropeptides .2011;45(5):317-22. doi: 10.1016/j.npep.2011.06.002


Nerve growth factor (NGF) has novel antidepressant-like properties in rats. David H. Overstreet, Kellie Fredericks, Darin Knapp, George Breese, John McMichael. Pharmacol Biochem Behav. 2010 Feb; 94(4): 553–560. doi: 10.1016/j.pbb.2009.11.010


Urinary Incontinence


Combination histamine and serotonin treatment after simulated childbirth injury improves stress urinary incontinence. Qi-Xiang Song, Brian M. Balog, Dan Li Lin, Hai-Hong Jiang, Volkan Gurel, James Spaulding, Julia Tobacyk, John McMichael, and Margot S. Damaser. Neurourology and Urodynamics, Neurourol Urodyn. 2016;35(6):703-10. doi: 10.1002/nau.22793.


Benign Prostatic Hypertrophy


A Trial Study: The Effect of Low Dose Human Chorionic Gonadotropin on the Symptoms of Benign Prostatic Hyperplasia. Michael F. Godschalk, Kenneth A. Unice, Donald Bergner, P. Gary Katz, Thomas Mulligan, John McMichael. J Urol. 2003 Oct;170(4 Pt 1):1264-9. doi: 0.1097/01.ju.0000084514.49252.64.


Modulating Activity of Human Chorionic Gonadotropin on Growth and Tumorigenesis of Prostate Cancer Cells. Jen Wei Chiao, Karen Turo, Yang Ming Yang, Eric Feldman, Frank Traganos, Delores Halicka, Ram Kancherla, S Robert Fatora, Tauseef Ahmed, John McMichael. Molecular Urology, Vol. 2, No. 2, 57-63, 1998.


Evaluation of a novel immunomodulator composed of human chorionic gonadotropin and bacillus Calmette-Guerin for treatment of canine mast cell tumors in clinically affected dogs. Carolyn J. Henry, Sue Downing, Robert C. Rosenthal, Mary Kay Klein, Kari Meleo, J. Armando Villamil, Linda S. Fineman, Dudley L. McCaw, Mary Lynn Higginbotham, John McMichael. Am J Vet Res. 2007;68(11):1246-51. doi: 10.2460/ajvr.68.11.1246


Enhancement of radiosensitivity of the MCF-7 breast cancer cell line with human chorionic gonadotropin. Sunthorn Pond-Tor, Ryan G. Rhodes, Paul E. Dahlberg, John T. Leith, John McMichael, Albert E. Dahlberg. Breast Cancer Res Treat. 2002 Mar;72(1):45-51. doi: 10.1023/a:1014964903540.


Open-Label Pilot Study of the Safety and Efficacy of LDI-200 in the Treatment of Cancer-Associated Pain. Lloyd Saberski, Hanne Peterson, John McMichael. The Pain Clinic, June 2001.


In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia. EJ Feldman, K Seiter, JW Chiao, HD Halicka, F Tragonos, SR Fatora, J McMichael, P Baskind, H Goff, M Beer, T Ahmed, Z Darzynkiewicz. Leukemia. 1998 Nov;12(11):1749-55. doi: 10.1038/sj.leu.2401196.